Adamantane-pyrido[2,3-d]pyrimidine Derivatives; Synthesis, Characterization and Investigation of Antimicrobial Study
نویسندگان
چکیده
Target molecules based on Adamantane-pyrido[2,3-d]pyrimidine derivatives were prepared. series using N-(hydroxyadamantan-1-yl)-5-(2,4-substitutedphenyl)-2-Methyl-4-Oxo-7-(2-oxo-2H-Chromen-3-yl)pyrido[2,3-d]Pyrimidine-3(4H)carboxamide (6a-j) was synthesized by reaction between 3-(2-chloroacetyl)-5-(2,4-substitutedphenyl)-2-Methyl-7-(2-Oxo-2H-Chromen-3-yl) pyrido[2,3-d]pyrimidin-4(3H)-one (5a-j) and 3-aminoadamantan-1-ol. These of Adamantane-pyrido[2,3-d]Pyrimidine investigated in vitro for their biological characteristics against the strains which isolated clinically confirmation structure done FTIR, 1H-NMR, 13C NMR LCMS. The newly gave promising antimicrobial activity.
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ژورنال
عنوان ژورنال: Oriental journal of chemistry
سال: 2023
ISSN: ['0970-020X', '2231-5039']
DOI: https://doi.org/10.13005/ojc/390219